Phenotypes associated with this allele

• Allele Symbol: Perp^tm2Att
• Allele Name: targeted mutation 2, Laura D Attardi
• Allele ID: MGI:4882063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Perp^tm2Att/Perp^tm2Att Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S4/SvJae	MGI:4882073

Genotype
MGI:4882073

cn1

• Allelic Composition: Perp^tm2Att/Perp^tm2Att; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased keratinocyte apoptosis ( J:167545 )

• in tamoxifen- and UVB-treated mice

skin inflammation ( J:167545 )

• in tamoxifen- and UVB-treated mice

increased skin squamous cell carcinoma incidence ( J:167545 )

• tamoxifen- and UVB-treated mice exhibit reduced latency to development of squamous cell and increased number of tumors per mouse compared with similarly treated wild-type mice

neoplasm

increased skin squamous cell carcinoma incidence ( J:167545 )

• tamoxifen- and UVB-treated mice exhibit reduced latency to development of squamous cell and increased number of tumors per mouse compared with similarly treated wild-type mice

decreased tumor latency ( J:167545 )

• tamoxifen-treated mice exhibit reduced latency to development of squamous cell carcinomas induced by UVB irradiation compared with similarly treated wild-type mice

immune system

skin inflammation ( J:167545 )

• in tamoxifen- and UVB-treated mice

cellular

decreased keratinocyte apoptosis ( J:167545 )

• in tamoxifen- and UVB-treated mice