Phenotypes associated with this allele

• Allele Symbol: Helb^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4881306
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Helb^tm1(KOMP)Vlcg/Helb^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5898152
cx2	Helb^tm1(KOMP)Vlcg/Helb^tm1(KOMP)Vlcg Trp53bp1^tm1Jc/Trp53bp1^tm1Jc	involves: 129 * C57BL/6NTac	MGI:5898295

Genotype
MGI:5898152

hm1

• Allelic Composition: Helb^{tm1(KOMP)Vlcg}/Helb^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal double-strand DNA break repair ( J:231089 )

• increased single-strand DNA formation due to increased DNA end resection in MEFs

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:231089 )

• increased single-strand DNA formation due to increased DNA end resection in MEFs

immune system

immune system phenotype ( J:231089 )

N • no significant change in B cell class switch recombination

reproductive system

reproductive system phenotype ( J:231089 )

N • despite defects in DNA repair, mice are fertile

Genotype
MGI:5898295

cx2

• Allelic Composition: Helb^{tm1(KOMP)Vlcg}/Helb^{tm1(KOMP)Vlcg}; Trp53bp1^tm1Jc/Trp53bp1^tm1Jc
• Genetic Background: involves: 129 * C57BL/6NTac

cellular

abnormal double-strand DNA break repair ( J:231089 )

• additive increase in DNA end resection in double knockout MEFs compared to single KO after treatment with radiomimetic drug neocarzinostatin (NCS)

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:231089 )

• additive increase in DNA end resection in double knockout MEFs compared to single KO after treatment with radiomimetic drug neocarzinostatin (NCS)