Phenotypes associated with this allele

• Allele Symbol: Ffar4^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4881214
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar4^tm1(KOMP)Vlcg/Ffar4^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5898007

Genotype
MGI:5898007

hm1

• Allelic Composition: Ffar4^{tm1(KOMP)Vlcg}/Ffar4^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown fat cell differentiation ( J:240649 )

• precursor cells from inguinal brown adipose tissue show impaired differentiation into brown adipocytes

• precursor cells from inguinal brown adipose tissue are insensitive to eicosapentaenoic acid treatment

abnormal white adipose tissue morphology ( J:240649 )

• fewer clusters of multilocular adipocytes in inguinal white adipose tissue following cold exposure

abnormal white fat cell differentation ( J:240649 )

• precursor cells from inguinal white adipose tissue show delayed differentiation at 3 days in culture but reach near wild-type levels by 7 days

abnormal beige fat cell physiology ( J:240649 )

• ability of eicosapentaenoic acid treatment to induce FGF21 expression and release is reduced in beige adipocytes

abnormal brown adipose tissue physiology ( J:240649 )

• following cold exposure brown adipose tissue shows an increase in leptin expression suggesting 'whitening' of the fat cells

abnormal white adipose tissue physiology ( J:240649 )

• significantly impaired browning of inguinal white adipose tissue following cold exposure with fewer clusters of multilocular adipocytes

homeostasis/metabolism

impaired adaptive thermogenesis ( J:240649 )

• about 20% of mice develop hypothermia within the first 24h of cold exposure (4^oC) compared to 0% of wild-type controls

• estimated core temperature is lower after 1 day of cold exposure and tends to remain lower after 7 days of cold exposure compared to wild-type controls

decreased oxygen consumption ( J:240649 )

• decrease in basal and CL316,243 (a beta3-adrenergic agonist) induced oxygen consumption

• blunted GW9508-induced increase in oxygen consumption compared to controls

decreased physiological sensitivity to xenobiotic ( J:240649 )

• impaired response to GW9508, an activator of FFAR4

cellular

abnormal brown fat cell differentiation ( J:240649 )

• precursor cells from inguinal brown adipose tissue show impaired differentiation into brown adipocytes

• precursor cells from inguinal brown adipose tissue are insensitive to eicosapentaenoic acid treatment

abnormal white fat cell differentation ( J:240649 )

• precursor cells from inguinal white adipose tissue show delayed differentiation at 3 days in culture but reach near wild-type levels by 7 days