Phenotypes associated with this allele

• Allele Symbol: Lep^m1Yst
• Allele Name: mutation 1, Yau-Sheng Tsai
• Allele ID: MGI:4880027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lep^m1Yst/Lep^m1Yst	C57BL/6J-Lep^m1Yst	MGI:4880644

Genotype
MGI:4880644

hm1

• Allelic Composition: Lep^m1Yst/Lep^m1Yst
• Genetic Background: C57BL/6J-Lep^m1Yst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:167736 )

adipose tissue

increased brown adipose tissue amount ( J:167736 )

• 2-fold increase in interscapular brown adipose tissue

increased white adipose tissue amount ( J:167736 )

• 8-fold

increased total body fat amount ( J:167736 )

• mice exhibit increased adiposity compared with wild-type mice that is nor as severe as in Lep^ob homozygotes

increased brown fat cell lipid droplet size ( J:167736 )

increased white fat cell number ( J:167736 )

• doubled in the gonadal white adipose tissue (WAT) increased in the inguinal WAT

increased white fat cell size ( J:167736 )

• in gonadal and inguinal white adipose tissue

abnormal gonadal fat pad morphology ( J:167736 )

• gonadal fat depots exhibit crown-like structures, reflecting the focal convergence of macrophages surrounding necrotic adipocytes, unlike in wild-type mice

increased inguinal fat pad weight ( J:167736 )

• 18-fold

homeostasis/metabolism

increased circulating glucose level ( J:167736 )

increased circulating insulin level ( J:167736 )

increased circulating leptin level ( J:167736 )

increased circulating cholesterol level ( J:167736 )

increased circulating triglyceride level ( J:167736 )

decreased body temperature ( J:167736 )

impaired glucose tolerance ( J:167736 )

insulin resistance ( J:167736 )

• more severe than in Lep^ob homozygotes

growth/size/body

increased heart weight ( J:167736 )

increased body weight ( J:167736 )

obese ( J:167736 )

• when fed standard chow

increased body length ( J:167736 )

increased kidney weight ( J:167736 )

increased liver weight ( J:167736 )

• triple compared with wild-type mice

liver/biliary system

increased liver weight ( J:167736 )

• triple compared with wild-type mice

hepatic steatosis ( J:167736 )

pale liver ( J:167736 )

renal/urinary system

increased kidney weight ( J:167736 )

polyuria ( J:167736 )

• slightly

behavior/neurological

abnormal eating behavior ( J:167736 )

• however, treatment with wild-type leptin reduces feeding

cardiovascular system

increased heart weight ( J:167736 )

digestive/alimentary system

increased defecation amount ( J:167736 )

• slightly

hematopoietic system

increased macrophage cell number ( J:167736 )

• gonadal fat depots exhibit crown-like structures, reflecting the focal convergence of macrophages surrounding necrotic adipocytes, unlike in wild-type mice

immune system

increased macrophage cell number ( J:167736 )

• gonadal fat depots exhibit crown-like structures, reflecting the focal convergence of macrophages surrounding necrotic adipocytes, unlike in wild-type mice