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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(H2-K1-tsA58)6Kio
transgene insertion 6, Dimitris Kioussis
MGI:4868476
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itga5tm1Hyn/Itga5tm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL MGI:4818936
cn2
 		Itga5tm2Hyn/Itga5tm2Hyn
Itgavtm2Hyn/Itgavtm2Hyn
Tg(H2-K1-tsA58)6Kio/0 		involves: 129 * C57BL/6 * SJL MGI:4818937


Genotype
MGI:4818936
cn1
Allelic
Composition		 Itga5tm1Hyn/Itga5tm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Tg(H2-K1-tsA58)6Kio mutation (2 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell adhesion ( J:161850 )
• endothelial cells showed reduced adhesion to fibronectin




Genotype
MGI:4818937
cn2
Allelic
Composition		 Itga5tm2Hyn/Itga5tm2Hyn
Itgavtm2Hyn/Itgavtm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Tg(H2-K1-tsA58)6Kio mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell adhesion ( J:161850 )
• endothelial cells when transiently transfected with cre, have reduced adhesion to fibronectin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory