Itgav^tm2Hyn
Targeted Allele Detail

Summary

• Symbol: Itgav^tm2Hyn
• Name: integrin alpha V; targeted mutation 2, Richard Hynes
• MGI ID: MGI:3759836
• Synonyms: alphav^flox
• Gene: Itgav Location: Chr2:83554796-83637261 bp, + strand Genetic Position: Chr2, 49.33 cM
• Alliance: Itgav^tm2Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94376
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted at the 5' start of exon 4 and additional loxP site was inserted downstream of exon 4 to create a floxed allele. The neo cassette was removed by cre-mediated recombination (source not specified). Insertion was confirmed by PCR and Southern blot. (J:94376, J:125508)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itgav^tm2Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itgav Mutation: 53 strains or lines available

References

• Original: J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
• All: 30 reference(s)