All Phenotypes Ccr2<tm2.1Ifc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccr2^tm2.1Ifc
targeted mutation 2.1, Israel F Charo
MGI:4868431

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4868437
cx2	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4868438

Allelic Composition	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm2.1Ifc mutation (2 available); any Ccr2 mutation (46 available)
Cx3cr1^tm1Litt mutation (6 available); any Cx3cr1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )

• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis with reduced monocyte infiltration into the central nervous system and decreased microglial cell activation compared with similarly treated wild-type mice

hematopoietic system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

Allelic Composition	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )

• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis compared with similarly treated wild-type mice

hematopoietic system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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