Analysis Tools
normal phenotype
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• mice exhibit normal lifespan, behavior, grooming habits, reproduction, and litter rearing
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Allele Symbol Allele Name Allele ID |
Mmp15tm1Kohl targeted mutation 1, Kenn Holmbeck MGI:4868411 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit normal lifespan, behavior, grooming habits, reproduction, and litter rearing
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice
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• at E12.5 in tamoxifen-treated mice starting at E7.5
• however, placenta develops normally in mice treated with tamoxifen at E12.5
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| N |
• tamoxifen-treated mice exhibit normal mammary gland involution
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• mice treated with tamoxifen at E7.5 exhibit compact structure, sparse vessels, and multiple dead cells around the fetal blood vessels unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die between E10.5 and E11.5
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• at E10.5
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• at E10.5
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• establishment of the labyrinthin layer of embryonic and maternal vascular interchange is retarded compared to in wild-type mice
• trophoblasts are present mostly as compact undifferentiated chorionic trophoblasts and far fewer as syncytiotrophoblast compared to in wild-type mice
• at E10.5, mice exhibit disruption of the labyrinth architecture compared with wild-type mice
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• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice
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• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice
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• at E10.5
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• at E10.5
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• at E10.5
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• at E10.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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