All Phenotypes Flot1<tm1.1Arte> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flot1^tm1.1Arte/Flot1^tm1.1Arte	involves: C57BL/6J	MGI:4868398
cx2	Flot1^tm1.1Arte/Flot1^tm1.1Arte Flot2^{Gt(258D8)Cmhd}/Flot2^{Gt(258D8)Cmhd} Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5697919
cx3	Flot1^tm1.1Arte/Flot1^tm1.1Arte Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?	involves: C57BL/6J	MGI:5697918

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte physiology ( J:166672 )

• fMLP-treated mice exhibit fewer neutrophils, monocytes, and lymphocytes in the air pouch and cardiac puncture compared to in similarly treated wild-type mice

• fMLP-treated neutrophils exhibit impaired uropod formation compared with similarly treated wild-type cells

impaired neutrophil chemotaxis ( J:166672 )

• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells

• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal

impaired neutrophil recruitment ( J:166672 )

homeostasis/metabolism

amyloid beta deposits ( J:212342 )

• MEFs transfected with GFP-APPswe and treated with antiserum to GFP show a slight but significant reduction in antibody uptake

• no colocalization of flotillin1 with APPswe

cellular

impaired neutrophil chemotaxis ( J:166672 )

• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells

• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal

nervous system

amyloid beta deposits ( J:212342 )

• MEFs transfected with GFP-APPswe and treated with antiserum to GFP show a slight but significant reduction in antibody uptake

• no colocalization of flotillin1 with APPswe

hematopoietic system

abnormal leukocyte physiology ( J:166672 )

• fMLP-treated mice exhibit fewer neutrophils, monocytes, and lymphocytes in the air pouch and cardiac puncture compared to in similarly treated wild-type mice

• fMLP-treated neutrophils exhibit impaired uropod formation compared with similarly treated wild-type cells

impaired neutrophil chemotaxis ( J:166672 )

• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells

• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal

impaired neutrophil recruitment ( J:166672 )

Allelic Composition	Flot1^tm1.1Arte/Flot1^tm1.1Arte Flot2^{Gt(258D8)Cmhd}/Flot2^{Gt(258D8)Cmhd} Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1^tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
Flot2^{Gt(258D8)Cmhd} mutation (0 available); any Flot2 mutation (37 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:212342 )

• reduced quantity of Abeta fragments

nervous system

amyloid beta deposits ( J:212342 )

• reduced quantity of Abeta fragments

Allelic Composition	Flot1^tm1.1Arte/Flot1^tm1.1Arte Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1^tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:212342 )

• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot

• clearly less Abeta as determined by ELISA

• 76% reduction in area covered by plaques

nervous system

amyloid beta deposits ( J:212342 )

• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot

• clearly less Abeta as determined by ELISA

• 76% reduction in area covered by plaques

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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