Phenotypes associated with this allele

• Allele Symbol: Aip^tm2.1Bra
• Allele Name: targeted mutation 2.1, Christopher A Bradfield
• Allele ID: MGI:4867825
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Speer6-ps1^Tg(Alb-cre)21Mgn Aip^tm2.1Bra	MGI:4867849
cx2	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra	B6.Cg-Aip^tm2.1Bra	MGI:4867848

Genotype
MGI:4867849

cn1

• Allelic Composition: Ahr^b-1/Ahr^b-1; Aip^tm2.1Bra/Aip^tm2.1Bra; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Aip^tm2.1Bra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice are resistant to dioxin-induced hepatic damage

homeostasis/metabolism

abnormal circulating alanine transaminase level ( J:166864 )

• doxin-treated mice do not exhibit an increase in serum alanine transaminase unlike similarly treated Aip^tm2.1Bra homozygotes

decreased physiological sensitivity to xenobiotic ( J:166864 )

• doxin-treated mice do not exhibit an increase in serum alanine transferase and are resistant to induced hepatic damage unlike similarly treated Aip^tm2.1Bra homozygotes

• however, doxin-treated mice exhibit increased liver and thymus weight similar to wild-type mice

cardiovascular system

patent ductus venosus ( J:166864 )

• in 1 of 8 mice

growth/size/body

decreased body size ( J:166864 )

• at 8 weeks

cellular

patent ductus venosus ( J:166864 )

• in 1 of 8 mice

Genotype
MGI:4867848

cx2

• Allelic Composition: Ahr^b-1/Ahr^b-1; Aip^tm2.1Bra/Aip^tm2.1Bra
• Genetic Background: B6.Cg-Aip^tm2.1Bra

cardiovascular system

cardiovascular system phenotype ( J:166864 )

N • mice do not exhibit patent ductus venosus