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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3cdtm2.1Tnr
targeted mutation 2.1, Martin Turner
MGI:4850049
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:4850095
cn2
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4850098
cn3
 		Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:4850097


Genotype
MGI:4850095
cn1
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (43 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
abnormal humoral immune response ( J:164283 )
• following immunization, the number of NP2-binding antibody forming cells in the bone marrow and spleen is reduced compared to in wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice

hematopoietic system
decreased germinal center B cell number ( J:164283 )
• following immunization
decreased spleen germinal center number ( J:164283 )
• following immunization, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization, high-affinity IgG1 antibody titers are modestly reduced compared to in similarly treated wild-type mice




Genotype
MGI:4850098
cn2
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:164283 )
N
• mice exhibit normal germinal center B cell numbers, NP-specific IgG1 titers, and immune memory response after immunization
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice

hematopoietic system
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice




Genotype
MGI:4850097
cn3
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (43 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:164283 )
• 7-fold following immunization with NP-KLH
• following immunization with SRBCs (sheep red blood cells)
decreased T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased CD4-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
• slightly in B cell follicles
• significantly in PNA+ IgD- germinal center areas
decreased T follicular helper cell number ( J:164283 )
• following immunization with NP-KLH of SRBCs (sheep red blood cells)
decreased CD8-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased spleen germinal center number ( J:164283 )
• following immunization with NP-KLH, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased spleen germinal center size ( J:164283 )
• following immunization with SRBCs (sheep red blood cells)
abnormal adaptive immunity ( J:164283 )
• following immunization and a later antigen boost, mice exhibit defective immunological memory compared with wild-type mice
decreased IgG1 level ( J:164283 )
• following immunization with NP33-BSA, the NP-specific IgG1 titers are decreased compared to in similarly treated wild-type mice
• following immunization with NP3-BSA, high-affinity NP-specific IgG1 response is severely impaired compared to in similarly treated wild-type mice
• fewer IgG1-secreting antibody forming cells are detected in the spleen and bone marrow compared to in wild-type mice

hematopoietic system
decreased germinal center B cell number ( J:164283 )
• 7-fold following immunization with NP-KLH
• following immunization with SRBCs (sheep red blood cells)
decreased T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased CD4-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
• slightly in B cell follicles
• significantly in PNA+ IgD- germinal center areas
decreased T follicular helper cell number ( J:164283 )
• following immunization with NP-KLH of SRBCs (sheep red blood cells)
decreased CD8-positive, alpha-beta T cell number ( J:164283 )
• modestly in the spleen without altering lymph node numbers
decreased spleen germinal center number ( J:164283 )
• following immunization with NP-KLH, the ratio of germinal centers per B cell follicle is reduced compared to in similarly treated wild-type mice
decreased spleen germinal center size ( J:164283 )
• following immunization with SRBCs (sheep red blood cells)
decreased IgG1 level ( J:164283 )
• following immunization with NP33-BSA, the NP-specific IgG1 titers are decreased compared to in similarly treated wild-type mice
• following immunization with NP3-BSA, high-affinity NP-specific IgG1 response is severely impaired compared to in similarly treated wild-type mice
• fewer IgG1-secreting antibody forming cells are detected in the spleen and bone marrow compared to in wild-type mice




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04/23/2024
MGI 6.23 		The Jackson Laboratory