About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(PDGFB)Cbet
targeted mutation 1, Christer Betsholtz
MGI:4849447
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4849465
cn2
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4849467
cn3
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL MGI:4849464
cn4
 		Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL MGI:4849466


Genotype
MGI:4849465
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Fabp4-lacZ)4Mosh mutation (1 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:166532 )
• mural cell (pericytes and vascular smooth muscle cells) densities are lower than in wild-type mice




Genotype
MGI:4849467
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Fabp4-lacZ)4Mosh/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Fabp4-lacZ)4Mosh mutation (1 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:166532 )
N
• mural cell (pericytes and vascular smooth muscle cells) densities are close to normal




Genotype
MGI:4849464
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology
abnormal astrocyte morphology ( J:166532 )
• astrocyte end-feet are mis-localized compared to in wild-type mice

cardiovascular system
abnormal capillary morphology ( J:166532 )
• capillary diameter is increased compared to in wild-type mice
decreased capillary density ( J:166532 )
• capillary density is reduced compared to in wild-type mice
abnormal pericyte morphology ( J:166532 )
• pericyte coverage is less than in wild-type mice but not as severely as in Pdgfbtm3.1Cbet homozygotes
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology




Genotype
MGI:4849466
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet
Pdgfbtm1Cbet/Pdgfbtm1Cbet
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFB)Cbet mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfbtm1Cbet mutation (0 available); any Pdgfb mutation (15 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability
abnormal astrocyte morphology ( J:166532 )
• astrocyte end-feet are mis-localized compared to in wild-type mice

cardiovascular system
abnormal capillary morphology ( J:166532 )
• capillary diameter is increased compared to in wild-type mice
decreased capillary density ( J:166532 )
• capillary density is reduced compared to in wild-type mice
abnormal pericyte morphology ( J:166532 )
• pericyte coverage is less than in wild-type mice but not as severely as in Pdgfbtm3.1Cbet homozygotes
impaired blood-brain barrier function ( J:166532 )
• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice
• however, imatinib-treatment reverses increased BBB permeability




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory