Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.1Jcbr mutation
(0 available);
any
Il6ra mutation
(35 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
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immune system
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• in mice infected with P. chabaudi
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• in mice infected with P. chabaudi
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• mice infected with P. chabaudi exhibit lower IL1b and TNF-alpha levels compared with control mice
• however, lethality is normal
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.1Jcbr mutation
(0 available);
any
Il6ra mutation
(35 available)
Tg(Alb1-cre)7Gsc mutation
(1 available)
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homeostasis/metabolism
adipose tissue
N |
• mice exhibit normal epigonadal fat pad weight and total body fat content
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• glucose uptake in white adipose tissue is reduced compared to in wild-type tissue
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immune system
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• in mice infected with P. chabaudi
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• during the steady state
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• in mice infected with P. chabaudi
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• mice infected with P. chabaudi exhibit lower IL1b and TNF-alpha levels compared with control mice
• however, lethality is normal
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growth/size/body
N |
• mice exhibit normal body weight
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behavior/neurological
N |
• mice exhibit normal food intake and activity levels
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liver/biliary system
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• in steady state, mice exhibit a reduction in hepatic glycogen levels compared with wild-type mice
• however, fasted mice exhibit normal hepatic glycogen levels
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endocrine/exocrine glands
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• in cultured islets under high glucose conditions
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• in cultured islets under low glucose conditions
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cellular
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• glucose uptake in white adipose tissue is reduced compared to in wild-type tissue
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