Phenotypes associated with this allele
Allelic Composition |
Apptm3.1Zhe/Apptm3.1Zhe
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Genetic Background |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Zhe mutation
(0 available);
any
App mutation
(89 available)
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normal phenotype
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• mice are viable and fertile with normal body weight and no impact on gamma-secretase processing or beta-amyloid production
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Zhe mutation
(0 available);
any
App mutation
(89 available)
Psen1tm1Mpm mutation
(4 available);
any
Psen1 mutation
(46 available)
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Amyloid beta deposits in Apptm3.1Zhe/Apptm3.1Zhe Psen1tm1Mpm/Psen1tm1Mpm mice
nervous system
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• mice exhibit increased amyloid load compared with Apptm1Ck Psen1tm1Mpm double homozygotes
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homeostasis/metabolism
mortality/aging
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• although born in Mendelian ratios, few mice survive to adulthood
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nervous system
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• neuromuscular junction exhibit mislocalization of choline transporters and reduced synaptophysin staining compared with wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm3.1Zhe mutation
(0 available);
any
App mutation
(89 available)
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Neuromuscular synapse defects in Apptm3.1Zhe/Apptm3.1Zhe Aplp2tm1Dbo/Aplp2tm1Dbo mice
mortality/aging
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• although born in Mendelian ratios, few mice survive to adulthood
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nervous system
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• neuromuscular junction exhibit mislocalization of choline transporters compared with wild-type mice
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