All Phenotypes App<tm3.1Zhe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm3.1Zhe
targeted mutation 3.1, Hui Zheng
MGI:4847574

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm3.1Zhe/App^tm3.1Zhe	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:4847593
cx2	App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:4847594
cx3	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1Dbo/App^tm3.1Zhe	involves: 129/Sv * 129X1/SvJ * C57BL/6	MGI:4847596
cx4	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm3.1Zhe/App^tm3.1Zhe	involves: 129/Sv * 129X1/SvJ * C57BL/6	MGI:4847598

Allelic Composition	App^tm3.1Zhe/App^tm3.1Zhe
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm3.1Zhe mutation (0 available); any App mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:166379 )

• mice are viable and fertile with normal body weight and no impact on gamma-secretase processing or beta-amyloid production

Allelic Composition	App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm3.1Zhe mutation (0 available); any App mutation (118 available)
Psen1^tm1Mpm mutation (4 available); any Psen1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Amyloid beta deposits in App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm mice

nervous system

amyloid beta deposits ( J:166379 )

• mice exhibit increased amyloid load compared with App^tm1Ck Psen1^tm1Mpm double homozygotes

homeostasis/metabolism

amyloid beta deposits ( J:166379 )

• mice exhibit increased amyloid load compared with App^tm1Ck Psen1^tm1Mpm double homozygotes

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1Dbo/App^tm3.1Zhe
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (31 available)
App^tm1Dbo mutation (4 available); any App mutation (118 available)
App^tm3.1Zhe mutation (0 available); any App mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:166379 )

• although born in Mendelian ratios, few mice survive to adulthood

nervous system

abnormal neuromuscular synapse morphology ( J:166379 )

• neuromuscular junction exhibit mislocalization of choline transporters and reduced synaptophysin staining compared with wild-type mice

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm3.1Zhe/App^tm3.1Zhe
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (31 available)
App^tm3.1Zhe mutation (0 available); any App mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neuromuscular synapse defects in App^tm3.1Zhe/App^tm3.1Zhe Aplp2^tm1Dbo/Aplp2^tm1Dbo mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:166379 )

• although born in Mendelian ratios, few mice survive to adulthood

nervous system

abnormal neuromuscular synapse morphology ( J:166379 )

• neuromuscular junction exhibit mislocalization of choline transporters compared with wild-type mice

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