About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Stat5a)#Mam
transgene insertion, Lothar Hennighausen
MGI:4847554
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:4847637
cn2
 		Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:4847638


Genotype
MGI:4847637
cn1
Allelic
Composition		 Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Stat5a)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:153755 )
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice

reproductive system
reproductive system phenotype ( J:153755 )
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice




Genotype
MGI:4847638
cn2
Allelic
Composition		 Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Stat5a)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:153755 )
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice

reproductive system
reproductive system phenotype ( J:153755 )
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory