Analysis Tools
homeostasis/metabolism
amyloidosis
(
J:156577
)
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• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex
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• amyloid beta deposition that appears first at about 3-4 months of age
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nervous system
microgliosis
(
J:156577
)
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• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited
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• amyloid beta deposition that appears first at about 3-4 months of age
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• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis
• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age
• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly
• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice
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• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
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• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice
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• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
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• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age
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• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice
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• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time
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• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice
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astrocytosis
(
J:156577
)
|
• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age
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• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
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hematopoietic system
microgliosis
(
J:156577
)
|
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited
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immune system
microgliosis
(
J:156577
)
|
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:156577 | ||
