Tg(Thy1-APPSw)10Jiri
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSw)10Jiri
• Name: transgene insertion 10, Jill C Richardson
• MGI ID: MGI:4843212
• Synonyms: TAS10
• Transgene: Tg(Thy1-APPSw)10Jiri Location: unknown
• Alliance: Tg(Thy1-APPSw)10Jiri page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSw)10Jiri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish mutations.

• Mutation details: The promoter drives brain-specific expression of the human cDNA with the Swedish double familial mutation (K670N, M671L). Nine lines were generated and line 10 exhibits highest expression. (J:128647)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128647 Richardson JC, et al., Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience. 2003;122(1):213-28
• All: 26 reference(s)