Phenotypes associated with this allele

• Allele Symbol: Mta1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4842891
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mta1^tm1a(EUCOMM)Wtsi/Mta1^tm1a(EUCOMM)Wtsi	129S/SvEvBrd-Mta1^tm1a(EUCOMM)Wtsi/WtsiH	MGI:5781674
hm2	Mta1^tm1a(EUCOMM)Wtsi/Mta1^tm1a(EUCOMM)Wtsi	involves: 129S7/SvEvBrd	MGI:6358202
ht3	Mta1^tm1a(EUCOMM)Wtsi/Mta1^+	129S/SvEvBrd-Mta1^tm1a(EUCOMM)Wtsi/WtsiH	MGI:5781673

Genotype
MGI:5781674

hm1

• Allelic Composition: Mta1^{tm1a(EUCOMM)Wtsi}/Mta1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: 129S/SvEvBrd-Mta1^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0002_2_B07

Data Sources

IMPC Data for Mta1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

hematopoietic system

thrombocytopenia ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:175295 )

♂

IMPC - WTSI

limbs/digits/tail

decreased caudal vertebrae number ( J:175295 )

IMPC - WTSI

skeleton

decreased caudal vertebrae number ( J:175295 )

IMPC - WTSI

decreased lumbar vertebrae number ( J:175295 )

IMPC - WTSI

increased sacral vertebrae number ( J:175295 )

IMPC - WTSI

abnormal bone mineralization ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 )

IMPC - WTSI

Genotype
MGI:6358202

hm2

• Allelic Composition: Mta1^{tm1a(EUCOMM)Wtsi}/Mta1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

mortality/aging ( J:278486 )

N • mice are viable

Genotype
MGI:5781673

ht3

• Allelic Composition: Mta1^{tm1a(EUCOMM)Wtsi}/Mta1⁺
• Genetic Background: 129S/SvEvBrd-Mta1^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0002_2_B07

Data Sources

IMPC Data for Mta1

homeostasis/metabolism

increased circulating triglyceride level ( J:175295 )

IMPC - WTSI

limbs/digits/tail

decreased caudal vertebrae number ( J:175295 )

IMPC - WTSI

skeleton

decreased caudal vertebrae number ( J:175295 )

IMPC - WTSI