Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation
(0 available);
any
Adarb1 mutation
(35 available)
Gria2tm1.1Phs mutation
(2 available);
any
Gria2 mutation
(75 available)
Tg(SLC18A3-cre)KMisa mutation
(2 available)
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behavior/neurological
N |
• mice exhibit normal motor function until 6 months of age
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nervous system
N |
• motor neuron death observed in Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa mice is prevented
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation
(0 available);
any
Adarb1 mutation
(35 available)
Tg(SLC18A3-cre)KMisa mutation
(2 available)
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mortality/aging
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• mice survive 82 weeks compared with 105 weeks for wild-type mice
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nervous system
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• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
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• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
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• mice exhibit fewer large neurons in the facial and hypoglossal nerves compared to in wild-type mice
• however, the number of neurons in the oculomotor nerve is normal
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• mice exhibit fewer large neurons compared to in wild-type mice
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• mice exhibit fewer large neurons compared to in wild-type mice
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• the number of myelinated axons in the ventral roots is decreased compared to in wild-type mice
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• between 1 and 2 months of age and slowly decreasing beyond 1 year of age
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behavior/neurological
N |
• mice exhibit normal withdrawal response to noxious stimuli
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• rotarod performance decreases from 5 weeks through 5 to 6 months of age and further after 18 months in comparison with wild-type mice
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• of the hind limb and tail
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• mice are hypokinetic unlike wild-type mice
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muscle
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• skeletal muscles exhibit pyknotic nuclear clumps unlike in wild-type mice
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growth/size/body