Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1(pb)Peli
• Allele Name: targeted mutation 1, Pentao Liu
• Allele ID: MGI:4840546
• Summary: 13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)H39Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840547
cn2	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)H8Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840548
cn3	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)H5Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840549
cn4	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)H12Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840550
cn5	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP2)H31Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840552
cn6	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP2)H32Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840557
cn7	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP2)H27Brd/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4840558
cn8	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP3)S2Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840553
cn9	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP2)S1Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840555
cn10	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP2)S2Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840556
cn11	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)S1Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840559
cn12	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP1)S2Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840560
cn13	Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor^+ TgTn(pb-sb-ATP3)S1Brd/0	involves: 129S7/SvEvBrd * FVB	MGI:4840561

Genotype
MGI:4840547

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)H39Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:166063 )

• no live-born mice are found but embryos are found at E11.5 indicating embryonic lethality

Genotype
MGI:4840548

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)H8Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, complete penetrance ( J:166063 )

• no live-born mice are found indicating embryonic lethality

Genotype
MGI:4840549

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)H5Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:166063 )

• fewer than expected live-born mice are found indicating embryonic lethality

neoplasm

abnormal tumor susceptibility ( J:166063 )

• survivors develop primarily solid tumors

Genotype
MGI:4840550

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)H12Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:166063 )

• fewer than expected live-born mice are found indicating embryonic lethality

Genotype
MGI:4840552

cn5

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP2)H31Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:166063 )

• fewer than expected live-born mice are found indicating embryonic lethality

Genotype
MGI:4840557

cn6

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP2)H32Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily hematopoietic tumors

increased leukemia incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

increased lymphoma incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

Genotype
MGI:4840558

cn7

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP2)H27Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily hematopoietic tumors

increased leukemia incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

increased lymphoma incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

Genotype
MGI:4840553

cn8

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP3)S2Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

prenatal lethality, complete penetrance ( J:166063 )

• no live-born mice are found indicating embryonic lethality

Genotype
MGI:4840555

cn9

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP2)S1Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily hematopoietic tumors

increased leukemia incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

increased lymphoma incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

Genotype
MGI:4840556

cn10

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP2)S2Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily hematopoietic tumors

increased leukemia incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

increased lymphoma incidence ( J:166063 )

• most mice develop aggressive leukemias and lymphomas

Genotype
MGI:4840559

cn11

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)S1Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily solid tumors

increased carcinoma incidence ( J:166063 )

• develop various carcinomas with poor differentiation and metastasis

increased sarcoma incidence ( J:166063 )

Genotype
MGI:4840560

cn12

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP1)S2Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop primarily solid tumors

increased carcinoma incidence ( J:166063 )

• develop various carcinomas with poor differentiation and metastasis

increased sarcoma incidence ( J:166063 )

Genotype
MGI:4840561

cn13

• Allelic Composition: Gt(ROSA)26Sor^tm1(pb)Peli/Gt(ROSA)26Sor⁺; TgTn(pb-sb-ATP3)S1Brd/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

mortality/aging

premature death ( J:166063 )

neoplasm

abnormal tumor susceptibility ( J:166063 )

• develop both solid and hematopoietic tumors with many mice having both types of tumors