All Phenotypes Adgra2<tm1Cjku> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgra2^tm1Cjku/Adgra2^tm1Cjku	involves: 129	MGI:4840267
cn2	Adgra2^tm1Cjku/Adgra2^tm2Cjku Tg(Tek-cre)12Flv/0	involves: 129/Sv * C3H * C57BL/6	MGI:4840270
cn3	Adgra2^tm1Cjku/Adgra2^tm2Cjku Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: 129/Sv * C57BL/6 * CBA	MGI:4840269

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:166127 )

• from E15.5 onwards; no embryos are recovered at E17.5

cardiovascular system

abnormal blood vessel morphology ( J:166127 )

• numerous packed endothelial cells with scant cytoplasm enveloped by pericytes are seen in CNS vascular malformations

abnormal angiogenesis ( J:166127 )

• CNS specific vascular patterning defects

abnormal vascular branching morphogenesis ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon

• filopodial extensions are reduced or absent in endothelial cells in the glomeruloid malformations and when present extend laterally rather than towards the ventricles

• however, sprouting is not affected in the embryonic diencephalon, mid- and hindbrain, or in nonneural tissues

abnormal perineural vascular plexus morphology ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

internal hemorrhage ( J:166127 )

• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube

• by E14.5 hemorrhagic glomeruloid malformations are seen in the telencephalon, ventral neural tube and forebrain ganglionic eminences

nervous system

abnormal neural tube morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube

abnormal telencephalon morphology ( J:166127 )

• decrease in angiogenic sprouting into the forebrain telencephalon and thickening of the underlying perineural vascular plexus resulting in a nearly avascular telencephalon

• by E14.5 defects in sprouting result in basally localized glomeruloid malformations and a distally avascular telencephalon

abnormal embryonic/fetal subventricular zone morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the forebrain ganglionic eminences

abnormal nervous system physiology ( J:166127 )

• beginning at E11.5 embryos display progressive central nervous system (CNS) hemorrhage originating in forebrain telencephalon and ventral neural tube

embryo

abnormal neural tube morphology ( J:166127 )

• by E14.5 hemorrhagic glomeruloid malformations are seen in the ventral neural tube

Allelic Composition	Adgra2^tm1Cjku/Adgra2^tm2Cjku Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129/Sv * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2^tm1Cjku mutation (0 available); any Adgra2 mutation (43 available)
Adgra2^tm2Cjku mutation (0 available); any Adgra2 mutation (43 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:166127 )

• basally localized glomeruloid malformations in hemorrhagic areas of the CNS

internal hemorrhage ( J:166127 )

• stated to be identical to the phenotype seen in mice homozygous for Gpr124^tm1Cjku

• forebrain hemorrhage

Allelic Composition	Adgra2^tm1Cjku/Adgra2^tm2Cjku Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic Background	involves: 129/Sv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:166127 )

• basally localized glomeruloid malformations in hemorrhagic areas of the CNS

abnormal vascular branching morphogenesis ( J:166127 )

• central nervous system (CNS) angiogenic arrest

internal hemorrhage ( J:166127 )

• stated to fully recapitulate the phenotype seen in mice homozygous for Gpr124^tm1Cjku

• forebrain hemorrhage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23