Phenotypes associated with this allele

• Allele Symbol: Emg1^tm1Hdin
• Allele Name: targeted mutation 1, Hao Ding
• Allele ID: MGI:4839753
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emg1^tm1Hdin/Emg1^tm1Hdin	involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR	MGI:4839756
cx2	Emg1^tm1Hdin/Emg1^tm1Hdin Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR	MGI:4839757

Genotype
MGI:4839756

hm1

• Allelic Composition: Emg1^tm1Hdin/Emg1^tm1Hdin
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:165972 )

• no mice are recovered after E3.5

embryo

abnormal preimplantation embryo development ( J:165972 )

embryonic growth arrest ( J:165972 )

• pre-implantation

absent blastocoele ( J:165972 )

absent inner cell mass ( J:165972 )

• mice fail to form Oct3/4+ or Nanog+ inner cell mass unlike wild-type mice

cellular

abnormal nucleolus morphology ( J:165972 )

• at E3.5, the nucleoli of embryos are large ring shapes unlike in wild-type mice

Genotype
MGI:4839757

cx2

• Allelic Composition: Emg1^tm1Hdin/Emg1^tm1Hdin; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

embryo

abnormal preimplantation embryo development ( J:165972 )

embryonic growth arrest ( J:165972 )

• at the morula stage

absent blastocoele ( J:165972 )