About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Epotm1Knni
targeted mutation 1, Knut Niss
MGI:4839526
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Epotm1Knni/Epotm1Knni
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S/Sv * C57BL/6 MGI:4839528
cn2
Epotm1Knni/Epotm1Knni
Tg(EIIa-cre)C5379Lmgd/0
involves: C57BL/6 * FVB/N MGI:4839527


Genotype
MGI:4839528
cn1
Allelic
Composition
Epotm1Knni/Epotm1Knni
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epotm1Knni mutation (0 available); any Epo mutation (31 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a decrease in the CD71- Ter119+ population, an intermediate erythroid progenitor stage in the bone marrow
• 50 days after tamoxifen induction with a subcutaneous pellet
• 50 days after tamoxifen induction with a subcutaneous pellet
• 50 days after tamoxifen induction with a subcutaneous pellet




Genotype
MGI:4839527
cn2
Allelic
Composition
Epotm1Knni/Epotm1Knni
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epotm1Knni mutation (0 available); any Epo mutation (31 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos died at 12.5 days post-coitum with severe defects in erythropoiesis

hematopoietic system
• significant reduction in RBCs in the liver





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory