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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam10tm1Beni
targeted mutation 1, Bernhard Nieswandt
MGI:4839221
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam10tm1Beni/Adam10tm1Beni
Adam17tm1.1Srj/Adam17tm1.1Srj
Tg(Pf4-icre)Q3Rsko/0 		involves: 129/Sv * 129S/SvEv * C57BL/6 MGI:4839228
cn2
 		Adam10tm1Beni/Adam10tm1Beni
Tg(Pf4-icre)Q3Rsko/0 		involves: 129/Sv * C57BL/6 MGI:4839227


Genotype
MGI:4839228
cn1
Allelic
Composition		 Adam10tm1Beni/Adam10tm1Beni
Adam17tm1.1Srj/Adam17tm1.1Srj
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1Beni mutation (0 available); any Adam10 mutation (37 available)
Adam17tm1.1Srj mutation (0 available); any Adam17 mutation (62 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:165863 )
• adult mice deficient in both metalloproteinases were rarely obtained (frequency: 2.5%)

hematopoietic system
abnormal platelet physiology ( J:165863 )
• when bone marrow is transplanted into irradiated wild-type mice, platelets treated with a calmodulin inhibitor (W7) or a mitochondrial damage reagent (CCCP) fail to shed GPVI in vitro unlike similarly treated wild-type cells
• however, in vivo shedding is normal

homeostasis/metabolism
abnormal platelet physiology ( J:165863 )
• when bone marrow is transplanted into irradiated wild-type mice, platelets treated with a calmodulin inhibitor (W7) or a mitochondrial damage reagent (CCCP) fail to shed GPVI in vitro unlike similarly treated wild-type cells
• however, in vivo shedding is normal




Genotype
MGI:4839227
cn2
Allelic
Composition		 Adam10tm1Beni/Adam10tm1Beni
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1Beni mutation (0 available); any Adam10 mutation (37 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:165863 )
• platelets exhibit impaired GPVI shedding triggered by calmodulin inhibition unlike in wild-type cells
• however, GPVI shedding induced by mitochondrial damage and antibody-induced GPVI ectodomain shedding in vivo are normal

homeostasis/metabolism
abnormal platelet physiology ( J:165863 )
• platelets exhibit impaired GPVI shedding triggered by calmodulin inhibition unlike in wild-type cells
• however, GPVI shedding induced by mitochondrial damage and antibody-induced GPVI ectodomain shedding in vivo are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory