Analysis Tools
cardiovascular system
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• hypertrophy in response to pressure overload is more severe than in wild-type controls
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• fibrosis in response to pressure overload is more severe than in wild-type controls
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• dilation in response to pressure overload is more severe than in wild-type controls
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• following 6 weeks of pressure overload, cardiac dilation, hypertrophy, interstitial fibrosis, and contractile impairment are more severe relative to similarly treated wild-type controls
• after pressure overload capillary density is significantly lower in mutant hearts compared to wild-type controls
• in the absence of stress overload no gross abnormalities are detected
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renal/urinary system
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• decrease in the level of hydrogen peroxide in the kidney
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homeostasis/metabolism
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• following 6 weeks of pressure overload, cardiac dilation, hypertrophy, interstitial fibrosis, and contractile impairment are more severe relative to similarly treated wild-type controls
• after pressure overload capillary density is significantly lower in mutant hearts compared to wild-type controls
• in the absence of stress overload no gross abnormalities are detected
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growth/size/body
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• hypertrophy in response to pressure overload is more severe than in wild-type controls
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cellular
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• fibrosis in response to pressure overload is more severe than in wild-type controls
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