Nox4^tm1.1Ams
Targeted Allele Detail

Summary

• Symbol: Nox4^tm1.1Ams
• Name: NADPH oxidase 4; targeted mutation 1.1, Ajay M Shah
• MGI ID: MGI:4838549
• Gene: Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
• Alliance: Nox4^tm1.1Ams page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the hearts and kidneys of homozygous mice. (J:165541)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox4 Mutation: 73 strains or lines available

References

• Original: J:165541 Zhang M, et al., NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
• All: 17 reference(s)