Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(SRF/VP16)Antu}
• Allele Name: targeted mutation 1, Alfred Nordheim
• Allele ID: MGI:4838411
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm1(SRF/VP16)Antu/Gt(ROSA)26Sor^tm1(SRF/VP16)Antu	involves: 129S1/Sv * 129X1/SvJ	MGI:5013392
ht2	Gt(ROSA)26Sor^tm1(SRF/VP16)Antu/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5013390

Genotype
MGI:5013392

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(SRF/VP16)Antu}/Gt(ROSA)26Sor^{tm1(SRF/VP16)Antu}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal optic nerve morphology ( J:172655 )

• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice

• however, lamination in the periphery is normal

abnormal ocular fundus morphology ( J:172655 )

• at P180

abnormal retina blood vessel morphology ( J:172655 )

abnormal retina photoreceptor morphology ( J:172655 )

• with rossette formation

retina photoreceptor degeneration ( J:172655 )

abnormal retina pigment epithelium morphology ( J:172655 )

abnormal retina inner nuclear layer morphology ( J:172655 )

• degeneration

retina outer nuclear layer degeneration ( J:172655 )

disorganized retina layers ( J:172655 )

• in all mice

retina degeneration ( J:172655 )

• at P180 near the optic nerve and scattered in the posterior part of the eye in 80% of mice

abnormal eye electrophysiology ( J:172655 )

• at P30, a-wave and b-wave amplitudes are smaller at higher light intensities compared with wild-type mice

• at P30 and P180, the ratio between the amplitudes of oscillatory potentials and b-waves is higher than in wild-type mice

• at P180, electroretinogram waveforms and parameters are different than in wild-type mice

• at P180, the b/a ratio is decreased compared to in wild-type mice

abnormal cone electrophysiology ( J:172655 )

• at P30 and P180, photopic b-wave and photopic 30 Hz flicker amplitudes are smaller than in wild-type mice

• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice

abnormal rod electrophysiology ( J:172655 )

• at P30, mice exhibit reduced amplitudes compared with wild-type mice

• at P180, scotopic a-wave and b-wave amplitudes are smaller than in wild-type mice

• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice

pigmentation

abnormal retina pigment epithelium morphology ( J:172655 )

lipofuscinosis ( J:172655 )

• in the eye at P180

growth/size/body

decreased body weight ( J:172655 )

cardiovascular system

abnormal retina blood vessel morphology ( J:172655 )

nervous system

abnormal retina photoreceptor morphology ( J:172655 )

• with rossette formation

retina photoreceptor degeneration ( J:172655 )

abnormal optic nerve morphology ( J:172655 )

• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice

• however, lamination in the periphery is normal

Genotype
MGI:5013390

ht2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(SRF/VP16)Antu}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

vision/eye

abnormal optic nerve morphology ( J:172655 )

• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice

• however, lamination in the periphery is normal

abnormal ocular fundus morphology ( J:172655 )

• at P180

abnormal retina blood vessel morphology ( J:172655 )

abnormal retina photoreceptor morphology ( J:172655 )

• with rossette formation

retina photoreceptor degeneration ( J:172655 )

abnormal retina pigment epithelium morphology ( J:172655 )

disorganized retina layers ( J:172655 )

• in 80% of mice

retina degeneration ( J:172655 )

• at P180 near the optic nerve in 60% of mice

abnormal eye electrophysiology ( J:172655 )

• at P180, electroretinogram waveforms and parameters are different than in wild-type mice

• at P180, the ratio between the amplitudes of oscillatory potentials and b-waves is higher than in wild-type mice

abnormal cone electrophysiology ( J:172655 )

• at P30 and P180, photopic b-wave and photopic 30 Hz flicker amplitudes are smaller than in wild-type mice

• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice

abnormal rod electrophysiology ( J:172655 )

• at P180, scotopic a-wave and b-wave amplitudes are smaller than in wild-type mice

• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice

pigmentation

abnormal retina pigment epithelium morphology ( J:172655 )

lipofuscinosis ( J:172655 )

• in the eye at P180

growth/size/body

decreased body weight ( J:172655 )

nervous system

abnormal retina photoreceptor morphology ( J:172655 )

• with rossette formation

retina photoreceptor degeneration ( J:172655 )

abnormal optic nerve morphology ( J:172655 )

• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice

• however, lamination in the periphery is normal

cardiovascular system

abnormal retina blood vessel morphology ( J:172655 )