All Phenotypes Cfp<tm2.1Song> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cfp^tm2.1Song
targeted mutation 2.1, Wen-Chao Song
MGI:4838300

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cfp^tm2.1Song/Cfp^tm2.1Song Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL	MGI:4838306
cn2	Cfp^tm2.1Song/Cfp^tm2.1Song Tg(EIIa-cre)C5379Lmgd/0	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:4838305

Allelic Composition	Cfp^tm2.1Song/Cfp^tm2.1Song Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfp^tm2.1Song mutation (0 available); any Cfp mutation (3 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired complement alternative pathway ( J:165497 )

• LPS-induced alternative pathway (AP) complement activation is impaired unlike in wild-type mice

decreased susceptibility to induced arthritis ( J:165497 )

• in a K/BxN model

skeleton