Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M7Btlr mutation
(1 available);
any
Tlr9 mutation
(65 available)
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immune system
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• in response to stimulation with oligodeoxynucleotides containing CpG motifs (CpG ODNs), a ligand for Toll-like receptor 9, peritoneal macrophages from mice homozygous for this mutation produce greatly reduced levels (vs. wild-type macrophages) of tumor necrosis factor (TNF-) alpha
• in contrast to their impaired response to a TLR9 ligand, homozygous mutant macrophages produce normal amounts of TNF-alpha upon stimulation with all other Toll-like receptor (TLR) ligands employed in the TLR Signaling Screen (for TLR1/2, TLR3, TLR4, TLR2/6 and TLR7)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M7Btlr mutation
(1 available);
any
Tlr9 mutation
(65 available)
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immune system
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• upon stimulation with oligodeoxynucleotides containing CpG motifs (CpG ODNs), a Toll-like receptor 9 ligand, peritoneal macrophages from mice heterozygous for this mutation produce levels of tumor necrosis factor (TNF-) alpha intermediate between those of wild-type and homozygous mutant mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.2Nemz mutation
(0 available);
any
Pld4 mutation
(26 available)
Tlr9M7Btlr mutation
(1 available);
any
Tlr9 mutation
(65 available)
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hematopoietic system
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N |
• no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages
• normal B-1 B cell and platelet numbers in peritoneum and normal NK T cell number
• normal marginal zone B cell number
• normal blood monocyte count
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homeostasis/metabolism
immune system
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N |
• normal spleen
• normal plasma CXCL10 levels
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Analysis Tools