Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6tm3.1Jxu mutation
(0 available);
any
Ncoa6 mutation
(100 available)
Tg(Cryaa-NCOA6*)AD5Cve mutation
(0 available)
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vision/eye
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• compared with Tg(Cryaa-NCOA6*)AD5Cve mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-NCOA6*)AD5Cve mutation
(0 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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vision/eye
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• eye size is increased compared to in Tg(Cryaa-NCOA6*)AD5Cve mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-NCOA6*)AD5Cve mutation
(0 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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vision/eye
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• the number of double strand break positive nuclei in the lenses is reduced 60% compared to in Tg(Cryaa-NCOA6*)AD5Cve mice
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• 1.35- to 1.65-fold compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
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• lens phenotype is more severe than in Tg(Cryaa-NCOA6*)AD9Cve mice
• the organelle-free zone at the center is absent unlike in wild-type mice
• the lens is filled with fibers containing nuclei unlike in wild-type mice
• lens deterioration is accompanied by posterior shift of the transitional zone, swollen and shortened fiber cell length, rounded end fragments, and cortical liquefaction unlike in wild-type mice
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• at E12.5, mice exhibit a posterior shift of some nuclei in the lens unlike in wild-type mice
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• at E15.5, mice exhibit some irregular lens fiber cells containing nuclei with abnormal morphology compared with wild-type mice
• fiber cells are expanded and skewed unlike in wild-type mice
• lens fibers lack the ball-and-socket structures found in wild-type mice
• embryonic and neonatal fiber cells contain more double-strand breaks than in wild-type mice
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• 3.84- to 4.75-fold
• in neonates and more pronounced at P21
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• lenses exhibit apoptosis unlike in wild-type mice
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Analysis Tools