Analysis Tools
mortality/aging
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• no viable mice are produced suggestion embryonic lethality
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Allele Symbol Allele Name Allele ID |
Rad50tm2.2Flv targeted mutation 2.2, Richard A Flavell MGI:4837634 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable mice are produced suggestion embryonic lethality
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• CD4 T cell differentiation is normal
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• stimulated CD4+ T cells are larger than similarly treated wild-type cells
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• in ovalbumin challenged mice
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• under Th1 conditions, splenocytes produce less IFN-gamma than similarly treated wild-type cells
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• under Th2 conditions, splenocytes produce less IL4, IL5, and IL13 compared with similarly treated wild-type cells
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• in splenocytes under Th1 conditions
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• in splenocytes under Th2 conditions
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• in splenocytes under Th2 conditions
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• in splenocytes under Th2 conditions
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• ovalbumin-treated mice exhibit no increase in eosinophils and lymphocytes in the bronchoalveolar lavage fluid, reduced infiltration of cells in the peribronchiolar and perivascular regions of the lung and decreased mucus production unlike wild-type mice
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• following methacholine treatment, ovalbumin sensitized and challenged mice fail to exhibit an increase in airway resistance unlike similarly treated wild-type mice
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• following methacholine treatment, ovalbumin sensitized and challenged mice fail to exhibit airway hyperresponsiveness unlike similarly treated wild-type mice
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• Th2 cells exhibit a dramatic increase in DNA methylation in the il4 promoter and CNS-1 region unlike similarly treated wild-type cells that exhibit a decrease in DNA methylation in this region
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• stimulated CD4+ T cells are larger than similarly treated wild-type cells
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• in ovalbumin challenged mice
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• under Th1 conditions, splenocytes produce less IFN-gamma than similarly treated wild-type cells
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• under Th2 conditions, splenocytes produce less IL4, IL5, and IL13 compared with similarly treated wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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