All Phenotypes Sp8<tm2Smb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sp8^tm2Smb
targeted mutation 2, Sheila M Bell
MGI:4837153

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sp8^tm1Smb/Sp8^tm2Smb Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:7437676
cn2	Sp8^tm1Smb/Sp8^tm2Smb Pax3^tm1(cre)Joe/Pax3⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7437668
cn3	Sp8^tm2Smb/Sp8^tm2Smb Tg(mI56i-cre,EGFP)1Kc/?	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N	MGI:4837173
cn4	Sp8^tm1Smb/Sp8^tm2Smb H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	MGI:7437666
cn5	Sp8^tm1Smb/Sp8^tm2Smb Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:7437667

Allelic Composition	Sp8^tm1Smb/Sp8^tm2Smb Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (29 available)
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal face development ( J:200761 )

• all (13 of 13) mice exhibited truncation of anterior facial structures

cleft upper lip ( J:200761 )

• 5 of 13 mice exhibited cleft lip and/or palate

cleft palate ( J:200761 )

• 5 of 13 mice exhibited cleft lip and/or palate

midline facial cleft ( J:200761 )

• all (13 of 13) mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a facial midline cleft

nervous system

abnormal telencephalon morphology ( J:200761 )

• mice exhibited malformations of the telencephalon

exencephaly ( J:200761 )

• only 1 of 13 mice exhibited exencephaly

growth/size/body

abnormal face development ( J:200761 )

• all (13 of 13) mice exhibited truncation of anterior facial structures

cleft upper lip ( J:200761 )

• 5 of 13 mice exhibited cleft lip and/or palate

cleft palate ( J:200761 )

• 5 of 13 mice exhibited cleft lip and/or palate

midline facial cleft ( J:200761 )

• all (13 of 13) mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a facial midline cleft

digestive/alimentary system

cleft palate ( J:200761 )

• 5 of 13 mice exhibited cleft lip and/or palate

vision/eye

vision/eye phenotype ( J:200761 )

N	• none of the 13 mice analyzed showed ocular hypertelorism

Allelic Composition	Sp8^tm1Smb/Sp8^tm2Smb Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (29 available)
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:200761 )

N	• 5 of 17 mice exhibited no detectable craniofacial defects

absent frontal bone ( J:200761 )

• 5 of 17 mice exhibited absence of the frontal bone

absent parietal bone ( J:200761 )

• 5 of 17 mice exhibited absence of the parietal bones

abnormal face development ( J:200761 )

• 11 of 17 mice exhibited truncation of anterior facial (snout) structures

cleft upper lip ( J:200761 )

• 7 of 17 mice exhibited cleft lip and/or palate

cleft palate ( J:200761 )

• 7 of 17 mice exhibited cleft lip and/or palate

small snout ( J:200761 )

midline facial cleft ( J:200761 )

• 5 of 17 mice exhibited a severe midline cleft

• 7 of 17 mice exhibited moderate midline defects

growth/size/body

abnormal face development ( J:200761 )

• 11 of 17 mice exhibited truncation of anterior facial (snout) structures

cleft upper lip ( J:200761 )

• 7 of 17 mice exhibited cleft lip and/or palate

cleft palate ( J:200761 )

• 7 of 17 mice exhibited cleft lip and/or palate

small snout ( J:200761 )

midline facial cleft ( J:200761 )

• 5 of 17 mice exhibited a severe midline cleft

• 7 of 17 mice exhibited moderate midline defects

nervous system

exencephaly ( J:200761 )

• 5 of 17 mice exhibited exencephaly

vision/eye

ocular hypertelorism ( J:200761 )

• 5 of 17 mice exhibited hypertelorism

digestive/alimentary system

cleft palate ( J:200761 )

• 7 of 17 mice exhibited cleft lip and/or palate

skeleton

absent frontal bone ( J:200761 )

• 5 of 17 mice exhibited absence of the frontal bone

absent parietal bone ( J:200761 )

• 5 of 17 mice exhibited absence of the parietal bones

Allelic Composition	Sp8^tm2Smb/Sp8^tm2Smb Tg(mI56i-cre,EGFP)1Kc/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:107576 )

N	• most mice do not exhibit exencephaly

abnormal olfactory bulb layer morphology ( J:107576 )

abnormal olfactory bulb external plexiform layer morphology ( J:107576 )

• reduced in size

abnormal olfactory bulb glomerular layer morphology ( J:107576 )

• stacked arrangement of glomeruli

abnormal olfactory bulb internal plexiform layer morphology ( J:107576 )

• lacking

small olfactory bulb ( J:107576 )

• noticably smaller

Allelic Composition	Sp8^tm1Smb/Sp8^tm2Smb H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (29 available)
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:200761 )

N	• mice exhibit no detectable craniofacial defects

Allelic Composition	Sp8^tm1Smb/Sp8^tm2Smb Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (29 available)
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:200761 )

N	• 9 of 10 mice exhibited no detectable craniofacial defects

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

growth/size/body

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

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