Analysis Tools
nervous system
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• pentylenetetrazol-treated mice exhibit reduced latency to seizure and increased seizure severity at threshold compared with similarly treated wild-type mice
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• mice exhibit a generalized pattern of sharp synchronous discharges unlike wild-type mice
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• at P2, neurons exhibit a depolarized resting membrane potentials, reduced firing threshold, and increased input resistance compared with wild-type neurons
• at P2, the interval between resting potential and firing threshold is compressed compared to in wild-type neurons
• at P2, steady state potassium ion current under voltage clamp at -20mV is reduced and neurons require less current to achieve a given spike frequency compared to in similarly treated wild-type neurons
• at 8 to 9 weeks of age, the interval between resting potential and threshold is compressed and maximal firing rate is reduced compared to in wild-type neurons
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behavior/neurological
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• mice exhibit normal motor coordination and learning, activity level and explorative behavior, and contextual and cued fear conditioning
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• pentylenetetrazol-treated mice exhibit reduced latency to seizure and increased seizure severity at threshold compared with similarly treated wild-type mice
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• mice exhibit a generalized pattern of sharp synchronous discharges unlike wild-type mice
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