Kcnh8^tm1.1Jmn
Targeted Allele Detail

Summary

• Symbol: Kcnh8^tm1.1Jmn
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 8; targeted mutation 1.1, Jeanne M Nerbonne
• MGI ID: MGI:7734730
• Gene: Kcnh8 Location: Chr17:52909737-53286222 bp, + strand Genetic Position: Chr17, 27.37 cM
• Alliance: Kcnh8^tm1.1Jmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:354329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and myristoyl-EGFP were inserted into exon 1 immediately upstream of the translation start site and an FRT flanked neo cassette, loxP site, and dTomato-2A-rtTA cassette were inserted downstream of exon 1 via homologous recombination. Flp-mediated recombination removed the EGFP and exon 1. (J:354329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh8 Mutation: 91 strains or lines available

References

• Original: J:354329 Hermanstyne TO, et al., Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons. J Gen Physiol. 2023 Sep 4;155(9)
• All: 1 reference(s)