Analysis Tools
renal/urinary system
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• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice
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Allele Symbol Allele Name Allele ID |
Tg(Pdgfrb-cre)#Rha transgene insertion, Ralf H Adams MGI:4835938 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with doxycycline since E16.5 and exposed to STZ to induce diabetes exhibit accelerated glomerular damage compared with similarly treated control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show increased vascularity in the regions adjacent to retinal veins
• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers
• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen
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• mice show increased retinal vein diameter at P5 and P10
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• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5
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• mice show increased vascularity in the regions adjacent to retinal veins
• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers
• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen
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• mice show increased retinal vein diameter at P5 and P10
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• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5
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• mice exhibit abnormal retinal venous plexus development in early postnatal life, with increased branching complexity in the peripheral half of the plexus, increased venous plexus vascular density but not arterial plexus density, and increased vascular area of the deep vascular plexus indicating venous plexus hypervascularity
• perivenous hypervascularity diminishes with time, although it is still evident at P10
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• fasting serum insulin is increased in 8-week-old mice
• however, fasting serum glucose is normal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| diabetic retinopathy | DOID:8947 | J:327000 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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