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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PrkcbM1Btlr
mutation 1, Bruce Beutler
MGI:4835545
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PrkcbM1Btlr/PrkcbM1Btlr C57BL/6J-PrkcbM1Btlr MGI:4835548
hm2
 		PrkcbM1Btlr/PrkcbM1Btlr involves: C57BL/6J MGI:5429191
ht3
 		PrkcbM1Btlr/Prkcb+ C57BL/6J-PrkcbM1Btlr MGI:4835547


Genotype
MGI:4835548
hm1
Allelic
Composition		 PrkcbM1Btlr/PrkcbM1Btlr
Genetic
Background		 C57BL/6J-PrkcbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:164864 )
• mice homozygous for this mutation display a severely reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll

hematopoietic system
decreased IgM level ( J:164864 )
• mice homozygous for this mutation display a severely reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll




Genotype
MGI:5429191
hm2
Allelic
Composition		 PrkcbM1Btlr/PrkcbM1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




Genotype
MGI:4835547
ht3
Allelic
Composition		 PrkcbM1Btlr/Prkcb+
Genetic
Background		 C57BL/6J-PrkcbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PrkcbM1Btlr mutation (1 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice

hematopoietic system
decreased IgM level ( J:164864 )
• mice heterozygous for this mutation display a reduced IgM antibody response to the T cell-independent model antigen 2,4,6-trinitrophenyl (TNP)-Ficoll, intermediate between the responses of wild-type and homozygous mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory