Prkcb^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkcb^M1Btlr
• Name: protein kinase C, beta; mutation 1, Bruce Beutler
• MGI ID: MGI:4835545
• Synonyms: Untied
• Gene: Prkcb Location: Chr7:121888327-122233625 bp, + strand Genetic Position: Chr7, 65.75 cM
• Alliance: Prkcb^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation has been identified as a T to C transition at position 1469 of the transcript, in exon 3 of 5 total exons. This changes the tyrosine at amino acid position 417 to a histidine. (J:164864)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcb Mutation: 37 strains or lines available

References

• Original: J:164864 Beutler B, Untied is an allele of Prkcb and causes defects in T-independent antibody responses. MGI Direct Data Submission. 2010
• All: 3 reference(s)