All Phenotypes Trip10<tm1.1Geha> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen germinal center morphology ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH), spleens exhibit less numerous and less prominent germinal centers with a reduced percent of B220+IgD^loFas+GL7+ B cells compared to in similarly treated wild-type mice

• however, the density of CD3+ cells is normal

decreased spleen germinal center number ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased spleen germinal center size ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased IgE level ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased IgG level ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

abnormal T cell physiology ( J:164363 )

• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells

decreased susceptibility to type IV hypersensitivity reaction ( J:164363 )

• mice sensitized to oxazalone exhibit less ear swelling, cellular infiltration, and edema compared with similarly treated wild-type mice

• lymph node cells transferred into wild-type mice do not confer the ability to mount a contact hypersensitivity response unlike when wild received wild-type cells

• however, dendritic cell mobilization is normal

hematopoietic system

abnormal spleen germinal center morphology ( J:164363 )

• however, the density of CD3+ cells is normal

decreased spleen germinal center number ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased spleen germinal center size ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased IgE level ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

decreased IgG level ( J:164363 )

• following exposure to Keyhole Limpet hemocyanin (KLH)

abnormal T cell physiology ( J:164363 )

• T cells exhibit defective adhesion to integrin and endothelial cells with impaired transepithelial migration compared with wild-type cells

Allelic Composition	Tg(TcraTcrb)425Cbn/0 Trip10^tm1.1Geha/Trip10^tm1.1Geha
Genetic Background	B6.Cg-Trip10^tm1.1Geha Tg(TcraTcrb)425Cbn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)425Cbn mutation (3 available)
Trip10^tm1.1Geha mutation (0 available); any Trip10 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:164363 )

N	• oxazalone-treated mice exhibit normal antigen-specific T effector cell generation

abnormal effector T cell morphology ( J:164363 )

• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred

decreased CD4-positive, alpha-beta T cell number ( J:164363 )

• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

hematopoietic system

abnormal effector T cell morphology ( J:164363 )

• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred

decreased CD4-positive, alpha-beta T cell number ( J:164363 )

• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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