Phenotypes associated with this allele

• Allele Symbol: Faim^tm1Kplm
• Allele Name: targeted mutation 1, Kong-Peng Lam
• Allele ID: MGI:4831133
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Faim^tm1Kplm/Faim^tm1Kplm	involves: 129P2/OlaHsd * C57BL/6	MGI:4831134

Genotype
MGI:4831134

hm1

• Allelic Composition: Faim^tm1Kplm/Faim^tm1Kplm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:164184 )

• mice die significantly earlier than wildtype in response to anti-FAS antibodies

immune system

increased B cell apoptosis ( J:164184 )

• more susceptible to activation induced cell death

increased thymocyte apoptosis ( J:164184 )

• enhanced susceptibility to FAS-induced apoptosis

liver inflammation ( J:164184 )

• more rapid progression of acute fulminant hepatitis in response to anti-FAS antibodies

hematopoietic system

increased B cell apoptosis ( J:164184 )

• more susceptible to activation induced cell death

increased thymocyte apoptosis ( J:164184 )

• enhanced susceptibility to FAS-induced apoptosis

liver/biliary system

liver hemorrhage ( J:164184 )

• within 2.5 hours after treatment with anti-FAS antibodies

increased hepatocyte apoptosis ( J:164184 )

• in response to anti-FAS antibodies

liver inflammation ( J:164184 )

• more rapid progression of acute fulminant hepatitis in response to anti-FAS antibodies

liver failure ( J:164184 )

• more rapid liver failure in response to anti-FAS antibodies

homeostasis/metabolism

increased circulating alanine transaminase level ( J:164184 )

• significant increase in the level of alanine aminotransferase in response to anti-FAS antibodies

increased susceptibility to xenobiotic induced morbidity/mortality ( J:164184 )

• mice die significantly earlier than wildtype in response to anti-FAS antibodies

cardiovascular system

liver hemorrhage ( J:164184 )

• within 2.5 hours after treatment with anti-FAS antibodies

cellular

increased B cell apoptosis ( J:164184 )

• more susceptible to activation induced cell death

increased thymocyte apoptosis ( J:164184 )

• enhanced susceptibility to FAS-induced apoptosis

increased hepatocyte apoptosis ( J:164184 )

• in response to anti-FAS antibodies

endocrine/exocrine glands

increased thymocyte apoptosis ( J:164184 )

• enhanced susceptibility to FAS-induced apoptosis