Faim^tm1Kplm
Targeted Allele Detail

Summary

• Symbol: Faim^tm1Kplm
• Name: Fas apoptotic inhibitory molecule; targeted mutation 1, Kong-Peng Lam
• MGI ID: MGI:4831133
• Gene: Faim Location: Chr9:98868426-98884074 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband F1
• Alliance: Faim^tm1Kplm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164184
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced by a neomycin resistance cassette. Western blot analysis confirmed that neither the long nor short isoform of FAIM nor a truncated protein was detectable in isolates from thymus and cerebellum. (J:164184)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Faim Mutation: 14 strains or lines available

References

• Original: J:164184 Huo J, et al., Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes. Cell Death Differ. 2009 Jul;16(7):1062-70
• All: 1 reference(s)