About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif4etm1.1Lfur
targeted mutation 1.1, Luc Furic
MGI:4830310
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif4etm1.1Lfur/Eif4etm1.1Lfur involves: 129X1/SvJ MGI:4830312
cn2
 		Eif4etm1.1Lfur/Eif4etm1.1Lfur
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4830313


Genotype
MGI:4830312
hm1
Allelic
Composition		 Eif4etm1.1Lfur/Eif4etm1.1Lfur
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4etm1.1Lfur mutation (0 available); any Eif4e mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:163589 )
• mouse embryonic fibroblasts exposed to RAS-induced transformation exhibit 4- to 10-fold fewer colonies than similarly treated wild-type cells
• however, cell proliferation is normal




Genotype
MGI:4830313
cn2
Allelic
Composition		 Eif4etm1.1Lfur/Eif4etm1.1Lfur
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4etm1.1Lfur mutation (0 available); any Eif4e mutation (42 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:163589 )
• at 7 months, mice exhibit fewer incidence of high grade prostate intraepithelial neoplasia due to delayed onset and decreased cell proliferation compared with Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
• mice do not exhibit infiltrating adenocarcinoma in the prostate unlike Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory