Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok3tm1Brs mutation
(0 available);
any
Dok3 mutation
(18 available)
|
|
|
hematopoietic system
|
• abnormal Mac-2-positive macrophages in the lung
|
immune system
|
• abnormal Mac-2-positive macrophages in the lung
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation
(0 available);
any
Dok1 mutation
(19 available)
Dok2tm1Yyam mutation
(0 available);
any
Dok2 mutation
(16 available)
Dok3tm1Brs mutation
(0 available);
any
Dok3 mutation
(18 available)
|
|
|
mortality/aging
|
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth
|
neoplasm
|
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age
|
|
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver
• the histiocytic sarcoma is highly invasive and transplantable
|
hematopoietic system
|
• abnormal Mac-2-positive macrophages in the lung
|
|
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response
|
immune system
|
• abnormal Mac-2-positive macrophages in the lung
|
|
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response
|