Phenotypes associated with this allele

• Allele Symbol: Cdkn2b^tm1Wff
• Allele Name: targeted mutation 1, Linda Wolff
• Allele ID: MGI:4829849
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdkn2b^tm1Wff/Cdkn2b^tm1Wff Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:4829853

Genotype
MGI:4829853

cn1

• Allelic Composition: Cdkn2b^tm1Wff/Cdkn2b^tm1Wff; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:163498 )

• an increased frequency of granulocyte-monocyte progenitors in the bone marrow

myeloid hyperplasia ( J:163498 )

• bone marrow cells demonstrate a significant increase in both mature myeloid, immature myeloid and monocytic cells

decreased erythroid progenitor cell number ( J:163498 )

• a decreased frequency of megakaryocyte-erythroid progenitors

abnormal megakaryocyte progenitor cell morphology ( J:163498 )

• a decreased frequency of megakaryocyte-erythroid progenitors

increased monocyte cell number ( J:163498 )

• show a 2-fold increase in the numbers of circulating monocytes at 5 to 7 months of age

immune system

myeloid hyperplasia ( J:163498 )

• bone marrow cells demonstrate a significant increase in both mature myeloid, immature myeloid and monocytic cells

increased monocyte cell number ( J:163498 )

• show a 2-fold increase in the numbers of circulating monocytes at 5 to 7 months of age