Phenotypes associated with this allele

• Allele Symbol: Vcl^tm1.1Whz
• Allele Name: targeted mutation 1.1, Wolfgang H Ziegler
• Allele ID: MGI:4822196
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vcl^tm1.1Whz/Vcl^tm1.1Whz	involves: 129/Sv * C57BL/6 * SJL	MGI:4822197

Genotype
MGI:4822197

hm1

• Allelic Composition: Vcl^tm1.1Whz/Vcl^tm1.1Whz
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Vcl^tm1.1Whz/Vcl^tm1.1Whz embryos are not viable and show exencephaly and increased cell death

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:163108 )

• die between E10.5 and E12.5

nervous system

increased embryonic neuroepithelium apoptosis ( J:163108 )

• notable at E10.5

incomplete rostral neuropore closure ( J:163108 )

• cranial neural folds fail to fuse by E10.5

absent brain ventricles ( J:163108 )

• absent at E10.5

exencephaly ( J:163108 )

• at E10.5

embryo

abnormal head mesenchyme morphology ( J:163108 )

• head mesenchyme is loosely organized and contains massively dilated blood vessels at E10.5

incomplete rostral neuropore closure ( J:163108 )

• cranial neural folds fail to fuse by E10.5

abnormal embryonic tissue physiology ( J:163108 )

• at E10.5 apoptosis is greatly increased primarily in mesenchymal tissues ventral to the spinal cord and in the neuroepithelium

cardiovascular system

dilated vasculature ( J:163108 )

• head mesenchyme is loosely organized and contains massively dilated blood vessels at E10.5

cellular

increased fibroblast adhesion ( J:163108 )

• MEFs display an increase in the size of adhesion sites

increased apoptosis ( J:163108 )

• at E10.5 apoptosis is greatly increased primarily in mesenchymal tissues ventral to the spinal cord and in the neuroepithelium

increased embryonic neuroepithelium apoptosis ( J:163108 )

• notable at E10.5

growth/size/body

abnormal head development ( J:163108 )

• at E10.5 head structures fail to fuse along the cranial midline

abnormal head mesenchyme morphology ( J:163108 )

• head mesenchyme is loosely organized and contains massively dilated blood vessels at E10.5