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Phenotype Image Detail
Image
Caption (A, A') Lateral view of whole wild-type (wt/wt) and Vcltm1.1Whz/Vcltm1.1Whz (ki/ki) embryos at E10.5. In the mutant embryo (A'), exencephaly resulting from a neural tube closure defect is shown (arrow heads). (B, B') Hematoxylin & Eosin staining of sagittal sections from wild-type and mutant embryos at E10.5. m, mesencephalon; t, telencephalon; h, heart; sc, spinal cord; drg, dorsal root ganglia; cg, cranial ganglia; bv, blood vessels. Corresponding nuclear (C, C') and TUNEL (D, D') staining in wild-type and mutant embryos at E10.5. Note increased cell death in mutant embryos (arrows). Scale bars: 500 um.
Copyright This image is from Marg S, PLoS One 2010;5(7):e11530, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:163108
Associated
Alleles
Symbol Name
Vcltm1.1Whz vinculin; targeted mutation 1.1, Wolfgang H Ziegler
Associated
Genotypes
Allelic Composition Genetic Background
Vcltm1.1Whz/Vcltm1.1Whz involves: 129/Sv * C57BL/6 * SJL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory