Phenotypes associated with this allele

• Allele Symbol: Tg(Dbh-cre/ERT2)198.1Hroh
• Allele Name: transgene insertion 198.1, Hermann Rohrer
• Allele ID: MGI:4821735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gata3^tm3Gsv/Gata3^tm3Gsv Tg(Dbh-cre/ERT2)198.1Hroh/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4821754

Genotype
MGI:4821754

cn1

• Allelic Composition: Gata3^tm3Gsv/Gata3^tm3Gsv; Tg(Dbh-cre/ERT2)198.1Hroh/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sympathetic ganglion morphology ( J:163233 )

• induction of cre activity in adult mice results in significant reduction in size of sympathetic ganglia

small superior cervical ganglion ( J:163233 )

• sympathetic ganglion size reduction leads to a small residual superior cervical ganglion (SCG) and stellate ganglon

abnormal sympathetic neuron innervation pattern ( J:163233 )

• absence of sympathetic innervation of eyelid musculature

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:163233 )

N • area of chromaffin cells in adrenal medulla of tamoxifen-treated adult mice is not different from controls

vision/eye

blepharoptosis ( J:163233 )

• functional deficit in mutants occurs as ptosis due to SCG abnormalities (absence of sympathetic innervation of eyelid musculature)