Analysis Tools
normal phenotype
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• viable and fertile with no gross abnormalities
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Allele Symbol Allele Name Allele ID |
Wdr77tm2Zwan targeted mutation 2, Zhengxin Wang MGI:4821121 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable and fertile with no gross abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings
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• expression analysis indicates a defect in epithelial cell differentiation
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• significant impairment in the development of branches and ductal tips in all 3 lobes
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• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium
• these ducts resemble immature prostate
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• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present
• these ducts resemble immature prostate
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• decrease in the number of branches and terminal duct tips in all 3 lobes
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• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells
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• multifocal hyperproliferative epithelial cells are observed in every prostate lobe
• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age
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• about half the size of control glands
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• similar in appearance to the dorsolateral lobe
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• decrease in the protein concentrations in prostate gland secretions from intact males
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• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings
|
|
|
• expression analysis indicates a defect in epithelial cell differentiation
|
|
|
• significant impairment in the development of branches and ductal tips in all 3 lobes
|
|
|
• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium
• these ducts resemble immature prostate
|
|
|
• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present
• these ducts resemble immature prostate
|
|
|
• decrease in the number of branches and terminal duct tips in all 3 lobes
|
|
|
• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells
|
|
|
• multifocal hyperproliferative epithelial cells are observed in every prostate lobe
• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age
|
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• about half the size of control glands
|
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• similar in appearance to the dorsolateral lobe
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• decrease in the protein concentrations in prostate gland secretions from intact males
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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