Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Scgb1a1tm1(cre/ERT)Blh mutation
(1 available);
any
Scgb1a1 mutation
(26 available)
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respiratory system
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• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice
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• after 6 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice
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neoplasm
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• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Scgb1a1tm1(cre/ERT)Blh mutation
(1 available);
any
Scgb1a1 mutation
(26 available)
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respiratory system
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• after 13 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice
• however, areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment
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neoplasm
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N |
• areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Sftpc-cre)1Blh mutation
(0 available)
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mortality/aging
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• most mice are sacrificed within a few weeks of birth with respiratory distress
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respiratory system
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• in mice surviving to 15 weeks
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• in mice surviving to 15 weeks
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• in mice surviving to 15 weeks
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• in mice surviving to 15 weeks
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• mice that survive to 15 weeks exhibit hyperplasia of the lung epithelium in the bronchi, bronchioles, and alveoli unlike wild-type mice
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• within a few weeks of birth
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neoplasm
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• in mice surviving to 15 weeks
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Analysis Tools