All Phenotypes Ptk2<tm2.1Guan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptk2^tm2.1Guan
targeted mutation 2.1, Jun-Lin Guan
MGI:4820570

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptk2^tm2.1Guan/Ptk2^tm2.1Guan	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:4820571
cn2	Ptk2^tm2.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N	MGI:4820572

Allelic Composition	Ptk2^tm2.1Guan/Ptk2^tm2.1Guan
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2^tm2.1Guan mutation (1 available); any Ptk2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162690 )

• no live homozygous embryos beyond embryonic day 10.5

Allelic Composition	Ptk2^tm2.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2^tm1.1Guan mutation (1 available); any Ptk2 mutation (90 available)
Ptk2^tm2.1Guan mutation (1 available); any Ptk2 mutation (90 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:162690 )

• fewer mutant embryos are recovered than Mendelian ratios starting at embryonic day (E)14.5; none are alive at birth

• no perivascular hemorrhages, normal vessels containing nucleated red blood cells, normal vascularization in placenta at E13.5

cardiovascular system

abnormal blood vessel morphology ( J:162690 )

• decreased number of vessels in the brain, spinal cord and skin at E13.5

dilated vasculature ( J:162690 )

• dilated vessels in the brain, spinal cord and skin at E12.5

increased vascular permeability ( J:162690 )

• increased permeability after recombinant adenoviruses encoding Cre infection of endothelial cells in vitro

cellular

increased apoptosis ( J:162690 )

• a slight increase in apoptosis in the liver at E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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