Phenotypes associated with this allele

• Allele Symbol: Ddr2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4820346
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddr2^tm1a(EUCOMM)Wtsi/Ddr2^tm1a(EUCOMM)Wtsi	FVB.B6N-Ddr2^tm1a(EUCOMM)Wtsi	MGI:5825256
cx2	Ddr2^tm1a(EUCOMM)Wtsi/Ddr2^tm1a(EUCOMM)Wtsi Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6N * FVB/N	MGI:5825262

Genotype
MGI:5825256

hm1

• Allelic Composition: Ddr2^{tm1a(EUCOMM)Wtsi}/Ddr2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: FVB.B6N-Ddr2^{tm1a(EUCOMM)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:236031 )

• mice are 25% smaller than wild-type littermates

reproductive system

infertility ( J:236031 )

• mice are sterile

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:236031 )

N • mammary gland development is not affected

Genotype
MGI:5825262

cx2

• Allelic Composition: Ddr2^{tm1a(EUCOMM)Wtsi}/Ddr2^{tm1a(EUCOMM)Wtsi}; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6N * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:236031 )

• mice develop primary mammary gland tumors with a similar latency and burden as single Tg(MMTV-PyVT)634Mul/0 mice

decreased metastatic potential ( J:236031 )

• mice show a reduction in the number of macroscopic and microscopic metastases in the lungs compared to single Tg(MMTV-PyVT)634Mul/0 mice

integument

increased mammary gland tumor incidence ( J:236031 )

• mice develop primary mammary gland tumors with a similar latency and burden as single Tg(MMTV-PyVT)634Mul/0 mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:236031 )

• mice develop primary mammary gland tumors with a similar latency and burden as single Tg(MMTV-PyVT)634Mul/0 mice